Abstract 10827: Ideal Cardiovascular Health Factors and Their Association with Subclinical Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis
Background: The AHA Strategic Impact Goal Through 2020 and Beyond defined an aggregate of 4 ideal cardiovascular (CV) health factors shown to be associated with healthy longevity. Association of ideal CV health factors with coronary artery calcium (CAC) and carotid intima-media thickness (CIMT) has not been described.
Methods: MESA is a population-based cohort of asymptomatic adults ages 45–84, free of CV disease. Agatston CAC score and mean maximum internal and common CIMT were measured at baseline. CAC score was repeated after a mean of 2.9 yrs. Ideal health factors included all 4 of the following - untreated blood pressure (BP) <120/80 mm Hg, total cholesterol (TC) <200 mg/dl, fasting blood glucose (FG) <100 mg/dl, and no tobacco > 12 mo. Non-ideal health factors were defined as intermediate - at least 1 factor treated to ideal levels or BP 120–139/80–89 mm Hg, TC 200–239 mg/dl, FG 100–125 mg/dl, or no tobacco ≤12 mo; poor - either current tobacco, BP, TC, or FG levels above intermediate cut-points. Those with both intermediate and poor factors were categorized as poor. Analyses were stratified by sex and adjusted for age and race/ethnicity. Baseline CAC and CIMT values were assessed using general linear models. Differences between health groups in CAC prevalence and annualized incidence were compared with logistic regression.
Results: Twelve % of men and 13% of women had all 4 ideal CV health factors (see Table); these adults had significantly lower CAC prevalence than those with intermediate or poor levels. Median CAC score among adults with ideal levels was significantly lower than adults with poor levels. Mean internal and common CIMT increased steadily with worsening health factor levels for both men and women. Differences in incident CAC between the 3 health groups were more pronounced among women than men.
Conclusions: Ideal levels of 4 major CV health factors are associated with lower burden and progression of subclinical disease, compared to intermediate or poor levels.
- © 2010 by American Heart Association, Inc.