Abstract 10463: Association of a Polymorphism of BTN2A1 With Hypertension in Japanese Individuals
Introduction: Hypertension is a major risk factor for atherosclerotic disease. We previously showed that the C→T polymorphism (rs6929846) in the promoter region of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) was significantly associated with myocardial infarction in Japanese individuals by a genome-wide association study.
Hypothesis: We assessed the hypothesis that the association of rs6929846 of BTN2A1 with myocardial infarction might be attributable, at least in part, to its effects on susceptibility to hypertension.
Methods: A total of 8567 Japanese individuals from two independent subject panels was examined: Subject panel A comprised 2317 hypertensive individuals and 1933 controls; and subject panel B comprised 2911 hypertensive individuals and 1406 controls. The relation of rs6929846 of BTN2A1 to hypertension was examined in both subject panels.
Results and Conclusions: The chi-square test revealed that rs6929846 of BTN2A1 was significantly related to the prevalence of hypertension in subject panels A (P = 1.0 × 10-10) and B (P = 0.0208). Multivariable logistic regression analysis with adjustment for covariates revealed that rs6929846 of BTN2A1 was significantly associated with hypertension in subject panels A (P = 2.6 × 10-6; dominant model; odds ratio, 1.69) and B (P = 0.0284; dominant model; odds ratio, 1.24), with the T allele representing a risk factor for hypertension. The rs6929846 was significantly associated with systolic blood pressure in subject panels A (P = 0.0063) and B (P = 0.0115) and in all subjects (P = 0.0001) and with diastolic blood pressure in subject panel B (P = 0.0323), with the T allele being related to high blood pressure. The risk T allele of rs6929846 of BTN2A1 was related to an increase in the serum concentration of high sensitivity C-reactive protein. The T allele increased the transcription activity of BTN2A1, and the over expression of BTN2A1 decreased the expression of elastin mRNA and increased the mRNA expression of matrix metallopeptidase 3 and interleukin 5. In conclusion, BTN2A1 may be a susceptibility gene for hypertension in Japanese individuals. Determination of genotype for this polymorphism may prove informative for assessment of the genetic risk for hypertension.
- © 2010 by American Heart Association, Inc.