Abstract 10440: Pre-procedural Elevated White Blood Cell Count and Neutrophil-Lymphocyte (N/L) Ratio are Predictors Of Ventricular Arrhythmias During PCI
Introduction: The absolute white blood cell (WBC) count and neutrophil to lymphocyte (N/L) ratio are predictors of death/myocardial infarction in patients who have undergone coronary angiography. We hypothesized that a pre-procedural elevated WBC count and an elevated N/L ratio would be a predictor of development of significant ventricular arrhythmias(sustained ventricular tachycardia/ventricular fibrillation) in subjects undergoing percutaneous coronary intervention (PCI)-because of increased systemic and coronary inflammation causing rapid thrombus formation and coronary occlusion.
Methods: We retrieved the data for all patients developing ventricular arrhythmia during PCI between 1999 to 2009 from our cath lab database (from 30,798 records), a total of 70 patients(Group I) and tabulated their WBC counts and absolute neutrophil and lymphocyte counts (as percentages) as well as N/L ratios. We compared the data with a random group of age,gender,medications and pre-existing condition matched controls (n=70) with similar lesion characteristics but without development of ventricular arrhythmias(Group II)during PCI from our database.
Results: Group I had a significantly higher total WBC count (means 14,344 Vs 6852; 95% CI; p=0.0004; n=70); neutrophil count (means 75.79% Vs 58.06% 95% CI; p<0.0001, n=70) and N/L ratio (means 3.79 Vs 1.56; 95% CI; p<0.0001, n=70)[means compared with t test].
Conclusions: Our data suggests a pre-procedural elevated WBC count, with an elevated percentage of neutrophils and an elevated N/L ratio are predictors of significant ventricular arrhythmias in patients undergoing percutaneous coronary intervention (PCI).
- © 2010 by American Heart Association, Inc.