Abstract 10395: The Impact of Different Definitions of Diastolic Dysfunction on the Cardiovascular Risk Profile of Affected Subjects. Can They be Used Equally?
Objectives: Left ventricular diastolic dysfunction (DDF) is associated with increased morbidity and mortality. Different definitions of DDF have been used in population-based, epidemiological studies. Our aim was to investigate the impact of different definitions of DDF on the cardiovascular risk profile of affected subjects.
Methods: Data from 2765 women and men aged 25–88 yrs from a population-based study (SHIP) with preserved left ventricular systolic function (LVEF >50%) underwent echocardiographic assessment including a comprehensive set of diastolic parameters. Five different definitions of DDF (Fig.1) were compared with respect to cardiovascular variables which are associated with DDF (including BMI, obesity, hypertension, diabetes and previous MI). Age- and gender-adjusted multivariable regression models were used to evaluate whether patterns of cardiovascular variables changed when different definitions were applied.
Results: Proportions of unclassifiable subjects and frequencies of participants with DDF varied significantly when different definitions for DDF were applied (Fig. 1). Accordingly, the cardiovascular risk profile among subjects with DDF changed substantially. For example, the proportions of hypertension and obesity varied from 53.7% to 71.2% and from 28.1% to 41.5% (p<0.001), respectively. In fully adjusted logistic regression models, age and gender were significantly associated with DDF independent of the definition used (OR for age 1.02–1.10, OR for gender 1.06–1.71), whereas other cardiovascular variables were not consistently associated with DDF.
Conclusions: Application of different definitions of DDF within one population results in substantial changes of the cardiovascular risk profile in affected subjects, making selection of the best definition difficult. Usage of definitions that were based on population-specific cut-off values yielded the most appropriate results.
- © 2010 by American Heart Association, Inc.