Abstract 10372: Assessment Of Right Ventricular Systolic Dysfunction Using Real Time Three Dimensional Echocardiography After Marathon Running
Background: Marathon running has increased in popularity over the past decade. The acute effects of strenuous exercise on cardiac function, in particular the right ventricle (RV), is a subject of recent interest. Although multiple studies have demonstrated 2D echocardiographic evidence of RV systolic dysfunction after marathon running, quantitative assessment of the RV is challenging due to its complex geometry. Little is known about the utility of real time 3D transthoracic echocardiography (RT3D TTE) in this patient population.
Objectives: The aim of the current study was to assess the extent and severity of change in RV function after completion of a half marathon, utilizing serial cardiac biomarkers, RT3D TTE and cardiac MRI (CMR).
Methods: A prospective study of 15 amateur athletes (32±6 years, 7 males) participating in the 2009 Manitoba Half Marathon was performed. Cardiac biomarkers including creatinine kinase (CK), myoglobin and troponin T (cTnT) were measured at baseline, immediately following the race and 1 week post marathon. RT3D TTE was performed at baseline, immediately following the race and 1 week post marathon. CMR was performed at baseline and immediately following the race.
Results: Myoglobin, CK and cTnT were all within normal range at baseline and increased significantly after the race. All patients demonstrated elevated cTnT post half marathon with a median value of 0.37 ug/L (interquartile range 0.26 to 0.74). Compared with baseline values, RV fractional area change assessed by 2D TTE, decreased significantly (41±2% vs. 33±4%, p<0.05). Similarly, RVEF by RT3D TTE decreased from 59±4% at baseline to 45±5% (p<0.05) immediately following the race. There was a strong linear correlation between RVEF as assessed by RT3D TTE and CMR after the half marathon (r=0.93, p<0.01). There was no evidence of myocardial edema on T2 imaging nor findings of delayed enhancement of the LV myocardium on CMR to suggest permanent necrosis. The RV abnormalities recovered 1 week post marathon.
Conclusion: In conclusion, RV systolic dysfunction transiently occurs after a half marathon and has been validated for the first time by RT3D TTE imaging.
- © 2010 by American Heart Association, Inc.