Letter by Quintão Regarding Article, “Association of Circulating Cholesteryl Ester Transfer Protein Activity With Incidence of Cardiovascular Disease in the Community”
To the Editor:
An interesting and yet provocative study by Vasan and coauthors (including J.M. Ordovas) appeared in Circulation1 reporting on the Framingham Heart Study and claiming that there is an inverse association of plasma cholesteryl ester transfer protein (CETP) activity with cardiovascular disease risk. The investigation used a reliable method of CETP measurement that incidentally also was used by Ordovas and coworkers in a previous report2 dealing with the Framingham Offspring Study, in which a CETP polymorphism (B2) was significantly associated with decreased CETP activity and a lower odds ratio for coronary heart disease. These incongruent results add to previous discrepant reports by other authors in the same Honolulu Heart Program population of increased3 or decreased4 coronary heart disease rates related to mutations that reduce plasma CETP activity. Such remarkable discrepancies in the interpretation of results based on population investigation of the importance of CETP in atherogenesis by use of measurement methods that seem reliable and with proper statistical treatment of all variables add to our frustrations in trying to understand the role of CETP, which is compounded by controversial data provided by several animal models.5
Vasan RS, Pencina MJ, Robins SJ, Zachariah JP, Kaur G, D'Agostino RB, Ordovas JM. Association of circulating cholesteryl ester transfer protein activity with incidence of cardiovascular disease in the community. Circulation. 2009; 120: 2414–2420.
Ordovas JM, Cupples LA, Corella D, Otvos JD, Osgood D, Martinez A, Lahoz C, Coltell O, Wilson PW, Schaefer EJ. Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study. Arterioscler Thromb Vasc Biol. 2000; 20: 1323–1329.
Curb JD, Abbott RD, Rodriguez BL, Masaki K, Chen R, Sharp DS, Tall AR. A prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderly. J Lipid Res. 2004; 45: 948–953.