Abstract 4706: Early Results From the Danish On-pump Off-pump Randomization Study (DOORS): A Randomized Study of 900 Patients Above 70 Years
Objectives: We aimed to compare the safety of Conventional Coronary Artery By-pass Grafting (CCABG) and Off-Pump Coronary Artery Bypass (OPCAB) in patients above 70 years.
Methods: Ninehundred patients above 70 years old were randomized to either CCABG or OPCAB surgery. Inclusion was performed in four different Danish heart centres between January 2005 and November 2008. An on-line randomization system was applied. Surgery, anaesthesia, and postoperative treatment were performed according to pre-defined protocols. Thirty days follow up was performed using biochemical markers of myocardial injury, electrocardiograms, clinical observation, and questionnaires. Data were presented in a blinded fashion to an independent end-point committee who assigned whether death, myocardial infarction or stroke had occurred. Data were analyzed according to intention-to-treat.
Results: The incidence of main events after 30 days is listed in the table⇓ below.
Conclusion: The DOORS-study is the largest randomized comparison of CCABG and OPCAB. Excellent survival rates were found in both groups. Differences in mortality and major early postoperative morbidity did not reach statistical significance. Long term follow-up, data on graft patency, quality of life, and calculations of socio-economic costs are still ongoing.