Abstract 4572: Elevation of Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels After Plaque Disruption
Introduction: Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) has been reported to be a novel biomarker for early diagnosis of acute coronary syndromes (ACS); however, it is unclear when serum sLOX-1 levels begin to increase before the onset of ACS. Lectin-like oxidized low-density lipoprotein receptor-1 that is expressed predominantly in lipid-laden area underneath a fibromuscular cap is released in part as sLOX-1 by proteolytic cleavage.
Hypothesis: We reasoned that plaque disruption, which exposed the lipid-burden to circulating blood, would play a key role of increasing the serum sLOX-1 levels.
Methods: We evaluated time-dependent changes in sLOX-1 levels during elective percutaneous coronary interventions (PCI) in the consecutive 43 patients with coronary heart disease (CHD). Intravascular ultrasound was used to confirm the occurrence of procedural plaque disruption during PCI. Serum sLOX-1 levels were measured immediately before PCI (baseline), 6 hours, 12 hours, and 24 hours after PCI.
Results and Conclusions: Procedural plaque disruption was seen in all patients. Serum sLOX-1 levels at baseline, at 6 hours, at 12 hours, and at 24 hours after PCI were 97±29pg/ml, 156±114pg/ml, 151±66pg/ml, 146±157pg/ml, respectively. The sLOX-1 levels at 6 hours, at 12 hours, and at 24 hours after PCI were significantly higher than those at baseline (p=0.0011, p<0.0001, and p=0.046, respectively). Elevation of sLOX-1 after procedural plaque disruption was found in 93% (40/43) of all patients, and the peak value of sLOX-1 was found at baseline in 7% (3/43), at 6 hours in 37% (16/43), at 12 hours in 33% (14/43), and at 24hours in 23% (10/43) of patients.
Conclusions: Procedural plaque disruption caused the significant elevation of serum sLOX-1 levels. The different kinetics of sLOX-1 release may reflect different stages of vulnerable plaque in CHD.