Abstract 4568: Coronary Blood Flow Reserve Improvement in Patients With Stable Coronary Artery Disease Treated With Ivabradine
Purpose. Although treatment with ivabradine reduces the incidence of hospital admissions for fatal and non-fatal myocardial infarction and coronary revascularization in a specific group of patients, there are no data concerning its effect on coronary circulation. The purpose of this study was to assess the effects of ivabardine on coronary flow and flow reserve in patients with stable coronary artery disease.
Methods. During diagnostic coronary angiography (baseline), fifteen patients with stable coronary artery disease underwent coronary blood flow velocity measurements (APV cm/s) of a non-culprit vessel, using a Doppler guidewire, at rest (r) and after adenosine administration to achieve maximal hyperemia (h). During programmed coronary intervention in the culprit vessel, the same measurements were repeated one week after treatment with ivabradine, both at the intrinsic heart rate (Ivabr-HR) and at a paced heart rate similar to that before treatment (Ivabr-Pace). Coronary flow reserve was defined as h-APV/r-APV.
Conclusions. This study shows for the first time that ivabradine treatment significantly improves coronary blood flow and flow reserve in patients with stable coronary artery disease.