Abstract 4423: Expected Outcomes of Superficial Femoral Artery Endovascular Interventions: A Meta-Analysis
A systematic review of English language literature from 1970 to 2009 identified 46 studies with 3189 patients reporting primary patency rates after consecutive SFA endovascular interventions. To more precisely estimate primary patency rates and other outcomes over two years, random effects meta-analysis was performed. Adjusting for pertinent baseline patient characteristics with meta-regression, the influence of definitive device (Stent or PTA) on primary patency was analyzed. Stent type (self expanding, balloon expanded, and stent grafts) was further examined. The pooled patient characteristics of the studies in the two groups (Stent and PTA) were remarkably similar except for the percentage of patients with total occlusions (41.8 vs 24.9; p<0.001). Meta-regression analyses, adjusted for percentage of patients with total occlusions, revealed that the primary patency rate is 10% higher for the Stent arm when compared to PTA arm at 12 months (p=0.04). Adjusted for relevant baseline characteristics, self expanding stent implantation is associated with the highest primary patency rate, 17% higher at 12 month followup compared to PTA, balloon expandable stents, and stent grafts (0.01). At 18 to 24 months follow-up, primary patency rates of SFA endovascular interventions seem to stably plateau at approximately 60%.