Abstract 4410: Spatial Distribution of Tissue Components in the Left Anterior Descending Coronary Arteries Detected by Optical Coherence Tomography Color-coded Maps
Background: It has been reported that thin-cap fibroatheroma (TCFA) clustered in the proximal sites of left ascending (LAD) and left circumflex coronary arteries. However, special distribution of each tissue component has not been elucidated well.
Methods: Forty coronary atherosclerotic lesions in 15 LAD of 15 patients with stable angina were visualized by optical coherence tomography (OCT, Light Lab). Tissue characteristics and thickness of each tissue component were measured and color-coded maps were reconstructed.
Results: The arc of the TCFA were negatively correlated with the distance from the branch within 5mm distal (r= −0.71, p=0.004) and proximal (r= −0.72, p=0.004) from the diagonal branch, and 5mm proximal from the septal branch (r= −0.62, p=0.02). Thickened fibrosis that run parallel to the arteries were seen in 10 LAD (10/15). Calcifications clustered around lipid pools. In cross-sectional analysis within 3mm distal and proximal from the septal branch, the maximum lipid areas were observed between 50 degrees and 70 degrees from the septal branch and the lipid areas were minimum in the opposite side of the septal branch (86%: 18/21), whereas the maximum lipid areas were observed in the opposite side of the diagonal branch and the lipid areas were minimum in the same side of the diagonal branch (75%: 18/24).
Conclusion: This is the first clinical demonstration of the special distribution of each tissue component by color-coded maps. The color-coded map of OCT is a promising method for the longitudinal evaluation of tissue characterization of coronary plaques and provides us with a new insight into spread of atherosclerotic lesions in coronary arteries.