Abstract 4167: Regional Myocardial Blood Flow by Stress 64-row Multidetector Computed Tomography Predicts Recovery of Left Ventricular Function After Coronary Artery Bypass Grafting
Introduction: The recent development of multidetector-row computed tomography (MDCT) has expanded the application of evaluation of myocardial perfusion. We assessed the hypothesis that evaluation of myocardial blood flow (MBF) by stress MDCT can predict left ventricular function after coronary artery bypass grafting (CABG).
Methods: One hundred sixty-two regional areas in eighteen patients (median age, 70 (range, 65– 80) years) were scheduled for CABG, were studied. Each patient underwent adenosine stress 64-row MDCT perfusion imaging and cine magnetic resonance imaging (MRI) in pre- and post-CABG. The MBF was estimated from the slope of the linear regression equation with Patlak plot analyses. Left ventricular function was assessed by measuring wall thickening (%WT) using cine MRI.
Results: The overall mean MBF was 1.39±0.79 and 1.92±0.75 ml/g/min in pre- and post-CABG, respectively (P<0.001). The postoperative mean MBF in ischemic areas significantly increased (pre- and post-CABG: 1.16±0.69 and 1.85±0.81 ml/g/min, respectively; P<0.001); however, the non-ischemic area showed no difference (1.98±0.78 and 2.12±0.58 ml/g/min, respectively; P=0.12). Revas-cularized areas with preoperative mean MBF ≥0.8 ml/g/min showed significantly higher postoperative MBF than those with preoperative mean MBF <0.8 ml/g/min (1.99±0.72 and 1.23±0.96 ml/g/min, respectively; P <0.05). Postoperative %WT with the revascularized areas of preoperative mean MBF ≥0.8 ml/g/min (pre %WT 63.2 and post %WT 79.9) was significantly improved than those with preoperative mean MBF <0.8 ml/g/min (pre %WT 68.8 and post %WT 73.9) (P<0.05).
Conclusions: In conclusion, this study suggested that this technique can provide useful information regarding both myocardial perfusion and recovery of left ventricular function after CABG.