Abstract 4147: The Incidence and Predictors of Late (Beyond 1 Year) Target Lesion Revascularization After Sirolimus-eluting Stent Implantation: From Three-year Follow-up of the j-Cypher Registry
Background: There is little long-term data to evaluate target lesion revascularization (TLR) after Sirolimus-eluting stent (SES). Also, it is not clear whether there really exists a late catch-up phenomenon.
Methods: To evaluate the incidence and the predictors of late (beyond 1-year) TLR after SES in comparison with bare-metal stents (BMS), 3-year data of the j-Cypher Registry were examined. Design of this registry was multi-center prospective enrollment of 15,216 consecutive patients for real world clinical entity.
Results: The incidence of TLR was analyzed from 17,050 lesions treated by SES and 1,259 lesions treated by BMS. The incidence of TLR after SES was 5.7% at 1-year, 8.1% at 2-year and 10.0% at 3-year. The incidences of TLR before and after 1-year in comparison with SES and BMS were shown in the figure⇓. Incidence of TLR within 1-year was significantly higher in BMS, but, incidence of late TLR was significantly higher in SES. Although, baseline characteristics of lesions treated with SES were significantly more complex than those of BMS, the tendencies of the increasing curve of TLR between SES and BMS were quite different before and after a point in time of 1-year. The multivariate analysis identified 7 independent predictors of late TLR as shown in the table⇓.
Conclusion: Late catch-up phenomenon was observed as indicated by the increasing incidence of late TLR after SES, but not after BMS.