Abstract 4006: Google-Assisted Recruitment of Peripartum Cardiomyopathy Patients and Predictors of Left Ventricular Recovery
Background: Peripartum cardiomyopathy (PPCM) is the onset of acute heart failure without demonstrable cause during the last month of pregnancy or within five months after delivery. The purpose of this study was to create a registry of patients with PPCM utilizing a novel web-based recruitment model and identify clinical factors that could serve to predict ejection fraction (EF) recovery.
Methods: Subjects identified using Google’s search-directed AdWords service and enrolled via the internet completed a standardized questionnaire, and submitted echocardiographic data that permitted evaluation of diagnosis and evolution of disease. Subjects meeting criteria were compared and categorized as recovered (EF>/=50) or nonrecovered (EF<50).
Results: Fifty-five subjects were enrolled. Mean age, parity, frequency of gestational hypertension (gHTN), and twin gestation were comparable to other contemporary U.S. cohorts. There was a statistically significant association between diagnosis during third trimester and persistent systolic dysfunction (25% v 4.7%, p=0.03). Gestational hypertension and breastfeeding were significantly associated with EF2>50% recovery (48.8% v 16.7%, p=0.046, and 39.5% v 8.3%, p=0.04, respectively). EF normalization occurred in all patients with EF1>/=35%.
Conclusions: Web-based recruitment yielded similar results to historical cohorts and appears to be a valuable tool for studying PPCM. Presence of gHTN, EF>/=35% at diagnosis, breastfeeding, and postpartum diagnosis were all significantly associated with recovery of systolic function.