Abstract 3906: Kansas City Cardiomyopathy Questionnaire Scores Correlate With NYHA Classification and Exercise Parameters in Patients With Hypertrophic Cardiomyopathy
Patients with hypertrophic cardiomyopathy (HCM) commonly have reduced exercise capacity measured by exercise testing. Exercise capacity in HCM has been correlated with NYHA classification. However, the relationship of other functional and quality of life measures to exercise capacity in HCM has not been evaluated. We hypothesized that the Kansas City Cardiomyopathy Questionnaire, validated as an effective health-related quality of life tool for patients with systolic heart failure, correlates with exercise measurements during cardiopulmonary exercise testing (CPX) in HCM.
Methods and results: 20 patients with HCM at a referral center were prospectively enrolled. Patients completed the KCCQ on the same day as CPX before test interpretation. KCCQ scores were compared with exercise parameters to determine correlation between the questionnaire components and exercise variables. For the cohort, mean age was 53±15.9; 45% male; 30% with resting left ventricular outflow gradient >30 mm Hg; mean NYHA class 2.4±.0.8. Correlation coefficients for KCCQ components versus NYHA, % predicted peak oxygen consumption (VO2), % O2 pulse, and VE-VCO2 slope, and exercise duration are shown in Table⇓.
Conclusions: In patients with HCM, KCCQ correlates with NYHA classification. The physical limitation score of the KCCQ demonstrated the strongest correlation with CPX measures of exercise capacity. The KCCQ may be a useful tool for assessing disease-specific quality of life and response to treatment in HCM.