Abstract 3900: Wireless Monitoring of Body Fluid Changes During Hemodialysis: Results From the Fluid Removal During Adherent Renal Monitoring (FARM) Study
Background: Prevention of excess fluid accumulation is an important goal in the management of heart failure. However, accurate detection of patient fluid buildup remains elusive. We report our experience with a low-profile, high-performance leadless fluid monitoring device that has the potential to improve heart failure patient care.
Methods: The FARM Study is a prospective, single center, non-randomized study. 25 patients undergoing regular hemodialysis were monitored with the AVIVO™ Mobile Patient Monitoring System (Corventis, Inc.), a wireless, non-invasive, multi-sensor vital signs monitor. Physiological variables, including fluid conductance, heart rate, and respiratory rate, were recorded continuously for two consecutive dialysis sessions and the inter-dialysis period. Fluid removal and weight change during dialysis were monitored at 30-min intervals.
Results: Fluid removal during dialysis totaled 3.4±1.6 L, and was associated with a progressive change in fluid conductance in all patients. This change was both significant (9.9±8.3 Ohms, 16.2±11.8%, p<0.0025) and linear (R2=0.98).
Conclusions: The low-profile, leadless and wireless AVIVO Monitoring System was able to accurately monitor patient fluid status during hemodialysis. The role of this non-invasive approach to predicting fluid retention is currently being tested in a large international multicenter study (MUSIC). The primary objective of MUSIC is to develop an algorithm using impedance changes in combination with additional sensors (respiratory rate, heart rate, heart rate variability, sleep posture, and activity index) to predict acute decompensation in patients with heart failure.