Abstract 3878: Depressed Cardiac Function, More Frequent Atrial Fibrillation and Reduced Depression in Patients With Relevant Alcohol Consumption in Dilated Cardiomyopathy: An Epidemiologic Cross-Sectional Analysis From the German Competence Net on Heart Failure
Hypothesis: Substantial alcohol consumption should contribute to heart failure and atrial fibrillation.
Methods: Demographic data of all patients enroled in the German national competence net on heart failure for alcohol consumption and cardiac symptoms were derived from 1200 pts with dilated cardiomyopathy (DCM), 269 pts with hypertrophic cardiomyopathy(HCM), 1095 pts with heart failure by CAD, 399 pts with hypertensive heart disease and failure(HHD) and 2313 hypertensive pts without heart failure(HT).
Results: An alcohol consumption of >2 drinks per day (1 dpd=0,25l beer) was attributed to pts groups with DCM in 6.6%, with HCM in 2.6%, with CAD in 4.1%, with HHD 4.8% and with HT in 6.0%. Differences for DCM and HT were significant, when compared with HCM and CAD (P<0,05). Men demonstrated a higher alcohol consumption than women in all groups (OR=5.1, 95% CI: 3.5–7.6, P<0.001). The amount of alcohol correlated positively with the left ventricular enddiastolic diameter(LVEDD) assessed by echocardiography in HT (Spearmans r=0.12, P<0.001), HHD (r=0.14, P=0.009), CAD (r=0.07, P=0.047) and showed a trend in HCM (r=0.08, P=0.207). Surprisingly there was no correlation of the LVEDD in pts with DCM (r=−0.02, P=0.567). Alcohol consumption showed a negative correlation with the NYHA-classification in DCM (r=−0.10, P<0.001) and HHD (r=−0.16, P=0.001). An increased alcohol consumption correlated positively the blood uric acid level or the allopurinol drug treatment in pts with HT (r=0.12, P<0.001 und r=0.05, P=0.022). Pts with relevant alcohol consumption showed less frequently depressive symptoms in DCM (r=−0.11, P<0.001), in HCM (r=−0.11, P=0.088), in CAD (r=−0.05, P=0.138), in HHD (r=−0.17) and in HT (r=−0.11, P<0.001). Alcohol consumption of more than 2 drinks per day was associated with a higher rate of atrial fibrillation in DCM and HCM (OR=2.4, 95% CI 1.5–3.8) only.
Conclusions: Pts with DCM and HT consume more alcohol than pts with HCM, CAD and HHD. The missing correlation of LVEDD in DCM with the amount of drinks per day could be due to the preexisting damage by the underlying disorder. An increased alcohol consumption goes along with a decrease of depressive symptoms, but is also associated with a higher incidence of atrial fibrillation in DCM and HCM pts only.