Abstract 3591: Paraoxonase Polymorphism is a Predictor of 5 year Mortality in Patients With Stable Multivessel Coronary Artery Disease
Background: Paraoxonase1 (PON1) has been considered candidate gene for CAD (Coronary Artery Disease). However, studies of the relationship between the PON1 polymorphism and risk of myocardial infarction are inconclusive. In addition, there is no data on the role of PON1 polymorphism in predicting cardiovascular events in a population known to have CAD.
Objective: In this ancillary study, we investigated the association of PON1 polymorphism and 5-year all cause mortality in a prospective cohort of patients with multi-vessel CAD.
Methods: 518 patients with multivessel stable CAD from the prospective, randomized, and controlled Medicine, Angioplasty, or Surgery Study II (MASS II), which was designed to compare medical treatment (n=166), angioplasty (n=178), and surgery (n=174). We studied the association of 5 polymorphisms located on PON1 gene (rs662, rs133006698, rs854560, rs705381, and rs3917464) and 5-year-mortality. The selected polymorphisms are the most studied and are distributed in all PON1 gene extension. Other risk factors within the mortality composite end-point of need of revascularization for refractory angina, myocardial infarction, death and stroke in patients with stable coronary artery disease at 5-year follow-up were also analyzed. DNA was obtained from each participant at MASS study randomization.
Results: At baseline the lipid profile had no difference regarding Cholesterol, LDL and Triglycerides among all studied SNPs; however the HDL levels were significantly lower in allele T’carriers at rs705381: TT (33.41 mg/dL), TC (36.72 mg/dL) and CC (37.94 mg/dL), p=0.0369. There is a significant statistical association between allele G rs13306698 and mortality (p=0.0113).
Conclusion: In our coronary artery disease population, in multivariable analysis, the allele G at rs13306698 is an independent predictor of mortality even though has a low frequency.