Abstract 3580: Relationship Between Polymorphisms Associated With Adrenergic Receptor Related Genes and Cardiovascular Events in Patients With Idiopathic Dilated Cardiomyopathy
Background: Sustained cardiac adrenergic stimulation has been implicated in the progression of cardiovascular events in patients with DCM.
Hypothesis: We hypothesized that combination of polymorphisms, which resulted in increased synaptic norepinephrine release and enhanced receptor function, would predispose patients with DCM to cardiovascular events.
Objectives: We evaluated the effect of polymorphisms in adrenergic receptor related genes on cardiovascular event-free survival in patients with idiopathic dilated cardiomyopathy (DCM).
Methods and Results: Genotyping at loci (ADRB1 Ser49Gly, Arg389Gly, and NET T-182C) was performed in 83 patients with DCM. Subjects were followed prospectively to the end point of cardiovascular events (mean follow-up period 45 months). The cardiovascular events were defined as cardiac death and emergent hospitalization due to congestive heart failure, arrhythmia, and cerebrovascular events. Analyses were conducted on the basis of the number of predicted risk genotypes a patient carried. We defined the ADRB1 Ser49 allele carrier, Arg389 allele carrier, and NET -182CC genotype as the predicted risk genotypes. Cardiovascular event-free survival was compared on the basis of the possession of the number of the predicted risk genotypes. Cardiovascular event-free survival was significantly better in patients with <3 predicted risk genotypes than those with 3 predicted risk genotypes.
Conclusions: Genotyping at three loci may be a useful approach for identification of patients with DCM at risk for cardiovascular events.