Abstract 3352: Interactions Between Sleep Disordered Breathing and Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy
OBJECTIVES: Our aim was to investigate the association between sleep disordered breathing (SDB) and atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM).
BACKGROUND: AF is highly prevalent in patients with HCM, and leads to significantly increased morbidity and mortality. Sleep disordered breathing (SDB) has been strongly associated with incidence, prevalence and recurrence of AF in patients without HCM, and whether this association applies to patients with HCM is not known.
METHODS: We prospectively performed overnight oximetry on consecutive echocardiographically confirmed HCM patients (n=91), who also underwent comprehensive clinical and echocardiographic evaluation. Presence and history of atrial fibrillation were correlated with the oximetry findings.
RESULTS: Patients with SDB had significantly higher left atrial volume index (LAVI) (58±19 vs. 42±13; P=0.0002). Those HCM patients with SDB had a higher prevalence of AF (40% vs. 11%; P=0.005). Increasing severity of SDB was accompanied by increases in LAVI and in AF prevalence. These associations remained significant after accounting for potential confounders in a multivariate analysis.
CONCLUSIONS: Our findings suggest that both the presence and severity of SDB may influence LAVI and the likelihood of AF in patients with HCM. SDB may therefore be an important and potentially modifiable cause of morbidity and mortality in this population.