Abstract 3073: Three-Dimensional Echocardiography for Detecting Ventricular-Ventricular Interaction and the Accuracy of Stroke Volume Determination in a Biventricular Model of Dyssynchrony
Background: Our goals were to verify whether three-dimensional echocardiography (3DE) could accurately differentiate the time difference between ventricular contractions when left and right ventricular (LV, RV) minimum global volumes were achieved in a dyssynchronized heart model.
Methods: Six fresh in-vitro porcine heart pumping models were set up at 30 –50 beats/min. LV and RV were set at 5 different stroke volumes (SV) (30, 35, 40, 45, 50ml). Synchronized and dyssynchronized pump settings were used with two different dyssynchronized settings: LV filled first and RV filled first. Time differences between LV and RV global volumetric maximum and minimum volume in both synchrony and dyssynchrony mode were measured. SVs acquired by 3DE were compared in synchronized and dyssynchronized groups, and also with the actual SVs measured directly from the pump.
Results: The mean time difference between RV and LV minimum global volume in synchrony was 0.11±0.15 s; whereas with dyssynchrony was 0.53±0.14 s (p<0.05). According to 3DE measurement, LV SV appeared no different between synchrony and dyssynchrony (p=0.32), but RV SV appeared somewhat different between synchrony and dyssynchrony condition, even though actual changes were underestimated (p=0.02).
Conclusions: 3DE is both feasible and reproducible to evaluate ventricular volume and interventricular dyssynchrony; 3DE is also more sensitive in detecting SV changes than 2DE. In dyssynchrony, RV SV or shape may be more easily affected than LV.