Abstract 3051: Race-Ethnic Differences in Left Ventricular Diastolic Function
Background: Racial-ethnic disparities exist in cardiovascular risk factors and heart failure morbidity and mortality. Left ventricular (LV) diastolic dysfunction is a predictor of outcome and of future occurrence of heart failure. It is unclear whether race/ethnic differences in diastolic function exist in the general population that may contribute to the disparities in cardiovascular outcomes.
Methods: Two-dimensional echocardiography was performed in the participants of the NINDS-funded Cardiac Abnormalities and Brain Lesions (CABL) study. LV diastolic function was assessed by traditional Doppler and by tissue Doppler imaging. Trans-mitral early (E) and late (A) components of diastolic flow, and early lateral mitral annulus excursion (E′) velocity were recorded and E/A and E/E′ ratios were calculated.
Results: The study cohort consisted of 632 subjects (96 blacks, 450 Hispanics, 86 whites, mean age 70.1±9.8 years; 64.1% women). After adjustment for age and sex, Hispanics showed lower E/A ratio and lower E′ compared with whites (Table⇓, model 1), whereas blacks had lower E′ than whites but no significant difference in E/A ratio. Blacks and Hispanics showed a non significant trend toward a higher E/E′ ratio compared with whites. The significance of the race-ethnic differences in diastolic function weakened and eventually disappeared when traditional cardiovascular risk factors and other confounders were included in the multivariate models (Table⇓, model 2).
Conclusions: Differences in LV diastolic function do exist among race/ethnic groups that might be involved in the disparities in cardiovascular burden reported in the literature. However, differences in modifiable cardiovascular risk factors and socio-demographic variables, rather than intrinsic race-ethnic differences, seem to explain most of the observed disparities in LV diastolic function.