Abstract 2653: Recovery of Cardiac Autonomic Function in Diabetic and Non Diabetic Patients With Acute Myocardial Infarction
Background. Depressed heart rate variability (HRV) predicts mortality in patients with acute myocardial infarction (AMI). HRV is markedly depressed in the acute phase of AMI but improves during follow-up. Diabetes mellitus (DM) may affect prognosis of AMI patients, but it is unknown whether it influences the temporal HRV improvement.
Methods. We studied 80 AMI patients treated by primary angioplasty. HRV was assessed on 24-hour ECG Holter recordings performed at pre-discharge, and at 1-month and 6-month follow-up.
Results. The population included 62 no-DM (58±10 years, 53 men) and 18 DM (64±10 years, 12 men) patients. The two groups did not differ as to clinical and angiographic findings, except for age (p=0.02). HRV results are summarised in the Table⇓. HRV at pre-discharge was lower in DM, compared to no-DM patients. A significant improvement of HRV was observed at follow-up in the 2 groups with no statistically significant differences for the changes, except for SDNN, which showed greater improvement in no-DM patients (p=0.04).
Conclusions: Among AMI patients, HRV was more significantly impaired in DM than in no-DM patients during the acute phase. A substantially similar improvement of HRV variables, however, was observed in DM and no-DM patients during follow-up.