Abstract 2501: Plasma Heart-type Fatty-acid Binding Protein Associates With Outcomes in Out-of-hospital Cardiac Arrest
Background: Plasma heart-type fatty acid binding protein (H-FABP), released from injured myocardium into circulation, is associated with survival in patients with heart failure and myocardial damage in myocardial infarction. The role of plasma H-FABP in early prediction of outcomes for out-of-hospital cardiac arrest (OHCA) remains unclear.
Hypothesis: Myocardial damage during cardiac arrest may result in elevated plasma H-FABP in OHCA survivors, which may have diagnostic significance.
Methods: There were 55 non-traumatic adult OHCA patients who were successfully resuscitated and prospectively enrolled. Plasma H-FABP level was checked by ELISA method at return of spontaneous circulation (ROSC), 1st and 3rd days following cardiac arrest. Baseline clinical characteristics, CPR process, biochemical measurements and outcomes of studied patients were collected and analyzed.
Results: The plasma H-FABP level on the 1st day following cardiac arrest was significantly higher in patients who failed to survive to hospital discharge (62.66±33.96 ug/L vs. 38.39±33.33 ug/L, p=.011). The survivors who survived longer had lower H-FABP level on the 1st day (p=.059). Using 20 ug/L as the cutoff value by receiver-operative characteristics curve analysis, patients with the H-FABP level above the cutoff value had higher in-hospital mortality (81% vs. 52%, p=.021). In patients with non-cardiac cause of cardiac arrest, plasma H-FABP was still higher in patients failed to survive hospital discharge than patients with hospital discharge (61.34±34.76 ug/L vs. 33.23±30.16 ug/L, p=.007).
Conclusion: Plasma H-FABP level, an indicator of cardiac damage, is significantly associated with in-hospital mortality in OHCA survivors.