Abstract 2487: Is CRP Related to Cardiovascular Death at Midterm Follow-up in Patients With Non Valvular Atrial Fibrillation: A Single-center Cohort Study?
Background Atrial fibrillation (AF) is associated with an increased risk of death and stroke compared to patients in sinus rhythm. The influence of an inflammatory state, as characterized by CRP levels, has not been clearly determined.
Aim We sought to investigate the clinical determinants of death occurrence among patients admitted for any type of nonvalvular AF (NVAF).
Methods 634 patients with an ECG documented AF were consecutively included and followed up. CRP levels at admission as well as risk factors and underlying clinical conditions were systematically recorded.
Results Hypertension was noted in 316 (58.4%) patients. Oral anticoagulation was prescribed at discharge in 366 patients (67.7%) and antiarrhythmics or beta blockers in 460 patients (85.0%). NVAF was paroxystic in 239 (44.2%), persistent in 151 (27.9%) and permanent in 151 (27.9%). The mean CHADS2 score was 1.69±1.30. The median CRP value was 7.30 (3.0–25.3). During a mean follow up of 1.85±1.39 years, 97 (17.9%) died and 8 (1.5%) had a stroke. The patient of the highest tertile of CRP have higher risk of stroke, death and AF recurence when compared to patients of the lowest tertile The Kaplan-Meier curves confirm that CRP highest tertile was associated with a higher risk of death (logrank <.0001). In the multivariate analysis, the significant predictors of death were age (OR 1.040, 95%CI, 1.009–1.072, p=0.0120) and CRP class (OR 3.529, 95%CI, 1.381–9.020, p=0.0166)
Conclusion CRP appears to be a risk marker of increased death event at midterm follow-up in patients with NVAF.