Abstract 2454: Impact of Early Statin Therapy on Development of Atrial Fibrillation at the Acute Stage of Myocardial Infarction
Background. The anti-inflammatory properties of statins may help to prevent atrial fibrillation (AF). The impact of statin therapy on the development of AFin acute myocardial infarction has not been studied.
Aim. To determine whether early statin therapy prevents acute atrial fibrillation in patients developing myocardial infarction
Methods and results. We analysed data on the prescription of statins within 48 hours of admission and the development of atrial fibrillation in 3396 patients with sinus rhythm developing an acute myocardial infarction and enrolled in the French registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction. The primary outcome measure was the development of atrial fibrillation at any time during the hospital stay. Atrial fibrillation developed in 7.0% (59/845) of patients without and in 3.9% (100/2551) of patients with early statin therapy (P<0.001). Multivariable analysis including the propensity score for early statin treatment showed that statin therapy was associated with a reduced risk of atrial fibrillation (odds ratio 0.64, 95% confidence interval [CI], 0.45– 0.92, P=0.017). A correlation with statin dose was observed: compared to patients without early statin therapy, the odds ratios (95% CI) for developing atrial fibrillation were 0.72 (0.49–1.04, P=0.080) in patients on a conventional dose, 0.52 (0.28 – 0.95, P=0.034) in patients on an intermediate dose, and 0.40 (0.18 – 0.92, P=0.030) in patients on a high dose.
Conclusion. This is the first study to document a correlation between early statin therapy and development of atrial fibrillation at the early stage of acute myocardial infarction.