Abstract 2371: Mean Platelet Volume and Prevalence of Peripheral Artery Disease
Introduction: Platelets play a pivotal role in the pathogenesis of atherosclerosis and peripheral artery disease (PAD). Mean platelet volume (MPV), a measure of platelet size available in every blood count, is increasingly recognized as an important marker of platelet activity. We hypothesized that MPV is associated with the prevalence of PAD.
Methods: We analyzed data from 6,354 participants aged 40 years and older from the 1999–2004 National Health and Nutrition Examination Survey. PAD was defined as an ankle brachial index ≥0.90 in either leg. Odds ratios and 95% confidence intervals were estimated by logistic regression.
Results: The prevalence of PAD in the cohort was 5.7 percent. MPV was significantly associated with PAD prevalence (tertile 1 – 4.4%, tertile 2 – 6.1%, tertile 3 – 7.0%, p for trend =0.003). After adjustment for age, sex, and race, the odds ratio of PAD comparing the highest tertile to the lowest tertile was 1.57 (95% confidence interval 1.15 to 2.13). After further adjustment for smoking status, hypertension, hypercholesterolemia, diabetes, glomerular filtration rate, body mass index, and platelet count the corresponding odds ratio was 1.58 (95% confidence interval 1.14 to 2.19). The addition of triglycerides, hemoglobin A1c, and C-reactive protein did not affect the results. The significant association between MPV and PAD was unchanged when MPV was used as a continuous variable.
Conclusions: Mean platelet volume, an inexpensive and readily available marker of platelet activity, is strongly and independently associated with PAD. These findings support the hypothesis that platelet size is an independent marker of PAD that could be used as a predictor of increased risk.
This research has received full or partial funding support from the American Heart Association, National Center.