Abstract 1885: Telomere Length Predicts Anaemia in Patients With Chronic Heart Failure and is Inversely Associated With Haemoglobin Levels
Objective Anaemia is frequently prevalent and associated with poor prognosis in patients with chronic heart failure (CHF). We hypothesize that cellular aging, indicated by short telomere length, contributes to the susceptibility to develop anaemia in patients with CHF. Therefore, we assessed the relationship between telomere length and anaemia in CHF patients.
Methods Telomere length was measured in peripheral leukocytes with real-time quantitative polymerase chain reaction in 875 CHF patients.
Results The median age of the patients was 73 years [interquartile range 64 –79], 61% male, left ventricular ejection fraction 30 [23– 44]%, estimated glomerular filtration rate (eGFR) 53 [40 – 68] mL/min/1.73m2, and Hb levels 8.4 [7.6 –9.2]. In total, 254 patients (29%) fulfilled the WHO criteria of anaemia. Anaemia was predicted by shorter telomere length (Odds ratio [OR] 1.31 per SD lower telomere length; 95% confidence interval [CI] 1.12 – 1.53; p=0.001) in univariate logistic regression analysis. This effect persisted after adjustment for age, gender and all baseline differences, which were eGFR, LVEF, a history of stroke and diabetes, age of onset of CHF, diastolic blood pressure, and BNP levels (OR 1.35 per SD lower telomere length; 95% CI 1.08 – 1.68; p=0.008). Finally, telomere length was independently, inversely associated with continuous Hb levels (correlation coefficient 0.137, p=0.002).
Conclusions We found that shorter telomere length independently predicted anaemia and was inversely associated with Hb levels. These findings possibly support the hypothesis that short telomere length contributes to the susceptibility to develop anaemia in patients with CHF.