Abstract 1787: A Genome-wide Association Study of Hypertension and Blood Pressure in Chinese Population
Hypertension is a common disease. A few genome-wide investigations of variants in hypertension and/or blood pressure have been reported in European population recently. Here we report a genome-wide association study of hypertension, systolic (SBP) and diastolic (DBP) blood pressure in Chinese population (454 hypertensives and 460 age, gender-matched normotensives) by using Ilumina Human 610-Quad within 620,901 SNPs. The top 20 loci at P<6 × 10−5 for two more traits included 1 locus (C10orf59/renalase gene) for hypertension and SBP, 2 loci (ATXN8OS/SCA8 and FBXO15 gene) for hypertension and DBP, 5 loci (EFCAB4B, LOC728739, LRIT2, NRG1 and PAK7 gene) for SBP and DBP, 1 locus (SYT4 gene) for hypertension, SBP and DBP. C10orf59/renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. Most of other genes are related to nervous system function. We also observe the association results of hypertension in Chinese population for those loci reported in CHARGE consortium, ATP2B1(P=0.127), CYP17A1(P=0.021), PLEKHA7(P=0.003), SH2B3(P=0.047), CACNB2(P=0.00999), CSK-ULK3(P=0.120), TBX3-TBX5(P=0.005) and ULK4(P=0.019). These findings will point to some novel targets for the prevention or treatment of hypertension.