Abstract 1697: Normal Right Ventricle Anatomy and Function in a Longitudinally Followed Cohort Free of Hypertension and Cardiovascular Disease: A Cardiovascular Magnetic Resonance Study of the Framingham Heart Study Offspring Cohort
Background: Right ventricular (RV) anatomy and function are diagnostic and prognostic determinants in cardiac and pulmonary disease. While data on normal left ventricular (LV) mass and volumes are well characterized by cardiovascular magnetic resonance (CMR), analogous data for the RV have not been defined in a longitudinally followed cohort free of hypertension and cardiovascular disease.
Methods: Study subjects were 1527 Cycle 7 participants of the FHS Offspring Cohort who underwent cine steady state free precession CMR encompassing both ventricles in 10-mm thick contiguous slices in the LV short axis orientation. Of these, 852 (age 61 ± 8yrs, 512 women) who were without hypertension at any cycle visit and were free of clinical cardiovascular disease (CVD) and asymptomatic LV systolic dysfunction were included in this analysis. RV epicardial and endocardial borders at end-diastole and RV endocardial borders at end-systole were manually traced with a summation of discs method used to determine end diastolic volume (EDV) and end systolic volume (ESV). RV mass was calculated by multiplying the end diastolic myocardial volume by the density of myocardium (1.05g/cm3).
Results: Baseline characteristics are presented along with RV parameters for each gender indexed to body surface area (BSA). BSA-normalized RV mass, EDV, and ESV s were significantly greater in men (Table⇓). The gender differences persisted after indexation to height, height2.7, body mass index (BMI) and fat free mass (data not shown). Further, RV mass and volume parameters significantly correlated (all p < 0.001) with analogous LV parameters in this population. Finally, RV ejection fraction (EF) was greater in women (p < 0.0001) than men.
Conclusion: In this largely Caucasian, longitudinally followed cohort free of hypertension and CVD, these data provide gender specific normative RV anatomic and function parameters that may be useful to distinguish RV health from disease.