Abstract 1696: Prognostic Implications of Concentric Remodeling in Ambulatory Patients With Coronary Heart Disease (From the Heart and Soul Study)
Background: Left ventricular (LV) concentric remodeling is associated with adverse outcomes in patients with hypertension. It is unknown whether concentric remodeling (CR) predicts adverse cardiovascular (CV) events in patients with stable coronary artery disease.
Methods: Standard transthoracic echocardiograms were performed in 973 participants from the Heart and Soul Study. Participants were divided according to geometric remodeling type: normal (31%), CR (27%), concentric LV hypertrophy (LVH, 33%), and eccentric LV hypertrophy (LVH, 9%). CV events were determined by two independent adjudicators and Cox proportional hazards models were used.
Results: After a mean 4.9 ± 1.5 years of follow-up, CV events occurred more frequently in those with concentric and eccentric LVH, but not in those with CR. (Figure⇓) After multivariate adjustment, concentric and eccentric LVH were associated with increased risk of death and heart failure hospitalization, whereas CR was not. (Table⇓)
Conclusion: CR is not associated with adverse CV events in ambulatory patients with CAD.