Abstract 1691: Inverse Association of Adiponectin and Left Ventricular Mass in African Americans; The Jackson Heart Study
Background: Most inter-racial studies have reported increased left ventricular mass (LVM) in African Americans (AA), but the specific metabolic causes are not well known. The adipokine hormone adiponectin (ADPN) affects glucose flux regulation, insulin sensitivity and lipid catabolism. In animal models ADPN has been shown to inhibit myocardium hypertrophic signaling. We aimed to quantify in AA the association between serum ADPN and LVM by ultrasound-measured ventricular mass.
Methods: In the Jackson Heart Study (JHS), a community-based cohort of AA, we investigated 1,485 participants (490 men) who were 21 to 84 years and did not have coronary heart disease or heart failure. The cross-sectional association between log ADPN and LVM indexed to height (LVMI; height2.7) was assessed with Spearman correlation coefficients (R) and multivariable linear regression, using forward stepwise modeling and effect decomposition.
Results: Mean (S.D.) ADPN levels were 6.05 (4.29) μg/mL in women and 3.89 (2.66) μg/mL in men; for LVMI they were 35.4 (9.2) g/m2.7 in women and 33.8 (7.9) g/m2.7 in men. ADPN was significantly associated with HDL-cholesterol (R = 0.43), insulin resistance - homeostasis, HOMA-IR (R = − 0.36), triglycerides (R = − 0.28), waist circumference, WC (R = − 0.26) and fasting plasma glucose, FPG (R = − 0.19). LVMI was significantly associated with body mass index, BMI (R = 0.38), WC (R = 0.32), FPG (R = 0.22) and HOMA-IR (R = 0.19). Hypertension and FPG were effect modifiers of the association between ADPN and LVMI. Among normotensives (N = 617), the correlation coefficient between ADPN and LVMI was R = − 0.10 (p = 0.02). ADPN was inversely and significantly associated with LVMI after minimal adjustment for age and sex (p = 0.02). Effects were reduced and became non-significant after further adjustment for FPG, or for HOMA-IR, or for measures of adiposity, dyslipidemia and leptin.
Conclusion: Adiponectin was inversely associated with LVM in normotensive AA. Our results suggest that adiponectin might be protective against left ventricular mass increase through pathways that involve glucose metabolism.