Abstract 1684: What Level of Plasma B-type Natriuretic Peptide is Related to Increased Risk of Onset of Cardiovascular Events in the General Population?
Background: Several community-based studies have shown a relationship between elevated plasma B-type natriuretic peptide (BNP) levels and risk of cardiovascular events (CVE) such as heart failure, stroke, and coronary heart disease. However, the threshold plasma BNP level signaling this increased risk of CVE in the general population remains unclear.
Methods: Subjects in this community-based study were recruited from the general population (n = 13,927; mean age = 63 yrs). Plasma BNP levels and established cardiovascular risk factors were determined at baseline. The cohort was divided into deciles according to plasma BNP levels in each sex, and the crude incidence of CVE in each decile was calculated. In addition, hazard ratios (HR) for CVE in each decile versus the 1st decile were determined by multivariate Cox regression models.
Results: The cohort was followed for 38,340 person-years, during which period 275 cases of CVE occurred (154 males, 121 females). The crude incidence of CVE was increased in the 9th and 10th deciles in males, and in the 10th decile in females (Figure⇓). The HR was also significantly increased in the 9th decile (HR = 2.24, 95% CI = 1.10 – 4.59; p < 0.05) and the 10th decile (HR = 3.47, 95% CI = 1.71–7.05; p = 0.001) in males, and the 10th decile only in females (HR = 2.76, 95% CI = 1.11– 6.84; p < 0.05).
Conclusion: Plasma BNP levels above the 80 percentile level in males and the 90 percentile level in females are the threshold levels signaling increased risk of CVE in the general population.