Abstract 1535: Lifelong Exercise Training Demonstrates a Dose Dependent Effect on Left Ventricular Compliance and Distensibility
Background: Sedentary aging leads to decreases in left ventricular (LV) chamber compliance and distensibility. Conversely, Masters’ athletes who train 6 –7 sessions per week throughout their adult lives maintain youthful LV compliance and distensibility (Circulation. 2004;110:1799 –1805). We hypothesized that preservation of compliance during aging may be possible with less rigorous training.
Methods: Men > age 65 (n=35) were recruited from:
the Aerobics Center Longitudinal Study, a well validated study which has prospectively documented lifelong exercise training patterns in subjects for the past 25 years,
regional road-race results and
US Masters competitions.
Subjects were stratified into ‘Quads’ based on their history of exercise training: Quad 1 (Q1) <2 sessions/wk (n=7); Q2=2–3/wk (n=5); Q3=4 –5/wk (n=11); Q4=6 –7/wk plus regular competitions (n=12). All subjects underwent simultaneous right heart catheterization and transthoracic echo to define LV pressure-volume curves. PCWP and LVEDV were measured at baseline, during decreased cardiac filling by lower-body negative pressure (−15 and −30 mm Hg) and after saline infusion (15 and 30 mL/kg).
Results: The pressure volume relationships are presented in Figure 1⇓. Thick lines=Quad pressure-volume relationships; thin lines=95% confidence intervals. Quad mean peak VO2±S.D. is also reported.
Conclusion: Lifelong exercise training has a dose-dependent effect on left ventricular chamber compliance and distensibility. Based on these findings, increasing levels of prolonged, sustained endurance training improve diastolic function and may help to prevent heart failure in the elderly.