Abstract 1458: Dyslipidemia and Risk of Atrial Fibrillation: The Niigata Preventive Medicine Study
Background: Dyslipidemia is an important risk factor for cardiovascular disease, and an association of dyslipidemia with atrial fibrillation (AF) has also been suggested. However, the results of cross sectional studies examining the association are controversial and there is no longitudinal study.
Methods: This prospective, community-based, observational cohort study was based upon annual health examinations in Japan. We studied the association of lipid profile with risk of new-onset AF in general population. Subjects who received lipid-lowering therapy were excluded.
Results: A total of 28,449 subjects were included in this study. During a follow-up of 4.5±2.7 years, AF developed in 265 subjects (0.9%). Total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol were associated with development of AF in women, but not in men (Table 1⇓). Triglycerides or lipid ratios were not associated with AF. In multivariable models adjusted for sex, age, LDL cholesterol, HDL cholesterol, triglycerides, body mass index, systolic and diastolic blood pressure, and fasting blood sugar, low HDL cholesterol was associated with AF in women, but not in men (Table 2⇓). In multivariable models, high LDL cholesterol was not associated with AF. The association of low HDL cholesterol with AF remained significant in women without risk factors for AF including treated hypertension, diabetes, or cardiac disease.
Conclusions: Low HDL cholesterol was associated with increased risk of new-onset AF only in women. Therapy to increase HDL cholesterol may provide additional benefit to reduce risk of AF in women.