Abstract 1441: Women’ Sleep Disturbance Associated With Coronary Heart Disease
PURPOSE: Sleep disturbance (SD) was the second most commonly reported prodromal symptom (PS) of MI among women in our large multi-site study. However, little is known about the characteristics and correlates of prodromal SD among women with MI. We performed a secondary analysis of data from a large study of racially diverse, post-menopausal (surgical or natural) women with MI to estimate the prevalence and describe the correlates of prodromal SD.
Methods: We analyzed data from 1169 women (42.1% Black, 43.5% White and 14.4% Hispanic) recruited from 15 sites across the U.S. All women were > 21 years of age and 4 – 6 months post-MI hospitalization. Data on 33 PS and on risk factors/comorbidities were collected using an Acute and Prodromal Myocardial Infarction Survey (MAPMISS). We used multiple logistic regression to examine correlates of SD (yes/no) and general linear models to examine correlates of SD severity (score range: 0 –21).
Results: SD was prevalent across ethnic groups: overall prevalence, 50.1%; Blacks, 51.4%; Hispanics, 52.4%; Whites, 48.1%. After adjusting for age, race, BMI and education, SD was significantly associated with conditions that affect sleep including chest pain, depression, congestive heart failure, chronic heart burn, and chronic back pain (p<0.05). SD was also associated with changes in thinking and remembering: women who reported cognitive changes were twice as likely to report SD as women who did not (OR 2.19; 95% CI 1.69 –2.85; p<0.001). There were no significant differences in SD prevalence or severity by race after adjusting for SD-related comorbidities, age, education and BMI. Notably, Black women reporting SD were significantly younger, heavier, more likely to also report cognitive changes, and less likely to report depression or emotional problems than White women with SD. It is striking that, even after taking into account sleep-affecting comorbidities and BMI, SD severity scores were higher for Black women than White women at the p=0.09 level.
Conclusion: SD was a common PS reported by women prior to MI regardless of race. More information is needed about SD among Black women and its implications for their cardiac health.