Abstract 1386: Association of the Extent of Perceived Mental Stress and Physical Inactivity, and the Extent of Coronary Artery Disease Diagnosed by Computed Tomography
Background: Psychological stress and lack of physical activity is known to have a negative effect on the health and well-being of coronary artery disease (CAD) patients. Current study evaluates the association between psychological stress, physical activity and subclinical atherosclerosis measured by coronary artery calcification (CAC).
Methods: Two hundred and forty subjects (age 60±9 years, 27% female) underwent CAC. Perceived mental stress (PMS) was studied using perceived stress questionnaire (PSQ, Levenstein, 1995). Physical activity status (MET) was measured using Danish physical activity questionnaire (DPAQ, Aadahl, 2003). Regression analysis was utilized for comparison of CAC, PMS and MET. The severity of CAC was CAC=0, 1≤CAC≤99, 100≤CAC≤399 and CAC≥400. PMS Score was calculated based on general perceived mental stress during the last two years. Total amount of MET was calculated based on an average weekday activity.
Results: PMS score increased substantially form CAC=0 to 1≤CAC≤99 to 100≤CAC≤399 to CAC≥400. Similarly, MET decreased significantly from CAC=0 to 1≤CAC≤99 to 100≤CAC≤399 to CAC≥400 (P<0.05) (figure⇓). Risk adjusted odds ratio (OR) of Highest vs. 2 lower tertiles of PMS was 3.9 (95 % 1.3–5.7, p=0.02) for CAC≥100 as compared to CAC=0. Similarly, the odds ratio of Lowest vs. 2/3 highest tertiles of MET was 2.8 (95% CI 1.2– 6.3, p=0.02) for CAC≥100 as compared to CAC=0. Furthermore, patients with high PMS and Low MET had maximum CAC.
Conclusion: Subclinical atherosclerosis measured by CAC increased with significant perceived mental stress and physical inactivity independent of age, gender and cardiac risk factors.