Abstract 1343: Decreased Physical Activity Relates to Poorer Diastolic Function and Increased LV Mass in Young People With and Without Type 2 Diabetes
In adults low level of physical activity is associated with cardiac morbidity. It is controversial whether low levels of activity in young people are also related to adverse cardiac findings. Our purpose was to determine the relationship between physical activity and LV mass and diastolic function in a high risk population: obese young people with and without type 2 diabetes (T2).
Methods: Physical activity was assessed using accelerometers worn by subjects for 7 days. Activity was divided into 3 categories based on activity counts per minute (Low, Mid, High activity). LV mass and diastolic function were assessed by m-mode and tissue Doppler echo for mitral Ea/Aa, and E/Ea ratios. Mean differences were evaluated by ANOVA after variance stabilizing procedures.
Results: 670 young people (ages 10–24 yrs, mean 18±3 yrs), were enrolled and divided into three groups: obese (n=234, BMI 37±6.9 kg/m2), T2 (n=195, BMI 37±9 kg/m2) and lean (n=241, BMI 21±2.5 kg/m2). Indexed LV mass was higher and diastolic function was lower in those with obesity and T2 diabetes and corresponded with lower activity levels. (p<0.05) (Figure⇓)
Discussion: Lower levels of activity were associated with both increased LV mass and decreased diastolic function compared to those with higher activity levels. Increased activity levels even in young people may be important for decreasing cardiac risk factors.