Abstract 1331: Factors Affecting Medication Adherence in Patients Taking Warfarin
Background: Medication adherence (MA) is the key for the treatment of chronic diseases. Warfarin has been widely used to prevent stroke and thrombus formation despite its narrow therapeutic range and fatal adverse reactions. This study aims to investigate the rate of MA in the patients taking warfarin, its influencing factors, and its relationship with anticoagulation control.
Methods and Results: A total of 204 patients taking warfarin completed the survey including self reported MA, warfarin knowledge, and self efficacy. To assess how MA is associated with anticoagulation control, the international normalized ratios (INRs) were reviewed in medical records. When MA was defined as taking warfarin following medical advice (frequency, dosage, time, and precautions) the ratio of MA was 56 people among 204 (27.45%). Adherent group had greater understanding about wafarin than non-adherent group measured by 10 items (7.20±1.69 vs 6.55±1.83, p<0.05) and had more significant self-efficacy (p<0.000). The patients who got an education session offered by the nurse in a group had also a higher knowledge score than those who had not (p<0.000). However, warfarin adherence did not affect the INR control.
Conclusions: The results show that knowledge of medication and self-efficacy exerts significant influence on MA in patients taking warfarin. Based on this, efforts should be concentrated on increment of patients’ knowledge and self-efficacy, the factors influencing MA. Further studies are needed to elucidate how nurses can impact patients’ better INR control and health outcomes. “This work was supported by the Korea Research Foundation Grant funded by the Korean Government” (KRF-2008 –331-E00391)