Abstract 1326: Electrocardiographic Q-waves in the Healthy Population is Associated With Increased Risk of Heart Disease and Mortality: Results From the 4th Copenhagen City Heart Study
Background: Electrocardiographic Q-waves in the healthy population is usually interpreted as a former silent myocardial infarction.
Objective: To determine the independent prognostic value of such Q-waves in a healthy population.
Methods: In Copenhagen City Heart Study 5,505 participants were without history of ischemic heart disease (IHD) and congestive heart failure (CHF). All participants were followed by national registers until 2007 with respect to the primary combined endpoint of hospital admission for IHD or CHF and total mortality.
Results: Abnormal Q-waves were present in the resting electrocardiogram of 115 of the participants; compared to those without the persons with Q-waves were significantly older with a higher incidence of hypertension and diabetes and elevated plasma proBNP concentrations. During follow-up 614 endpoints occurred. Q-waves were associated with increased risk of the primary endpoint (see Figure⇓) even after adjustment for age, sex, body mass index, hypertension, diabetes, atrial fibrillation, and plasma proBNP (hazard ratio 1.64 (1.14 –2.36), p=0.007). The size of the Q-waves were linearly correlated with increasing risk of the primary endpoint (p<0.001), but even very small Q-waves were significantly associated with increased risk (p<0.001).
Conclusions: The presence of Q-waves is associated with increased risk of mortality and development of IHD and CHF in the community.