Abstract 1297: Prevalence and Incidence of CV Disease Risk Factors in Patients With Vitamin D Deficiency
Background: Vitamin D (Vit D) deficiency is prevalent in the U.S. population. Several physiologic mechanisms may link Vit D deficiency to cardiovascular (CV) disease, including loss of anti-inflammatory actions, secondary hyperparathyroidism resulting in insulin resistance and diabetes, and induction of the renin-angiotensin-aldosterone system resulting in hypertension and adverse cardiac remodeling.
Methods: We prospectively analyzed patient (pt) data from an integrated healthcare system to assess the relationship between Vit D deficiency and both prevalence and incidence of CV risk factors. 25-hydroxy Vit D (25-OH Vit D) levels were determined by the hospital laboratory and pts (N=41,497; age 55±21, male 25.2%) were grouped as no deficiency (>30 ng/mL), moderate (15–30 ng/mL), or severe deficiency (<15 ng/mL). CV risk factors were determined by ICD-9 codes from electronic medical records at baseline and during the average 1.3-y (max 9.3-y) follow-up.
Results: CV risk factor prevalence by 25-OH Vit D is shown in Table 1⇓, and incidence rates and their hazard ratios are given in Table 2⇓. Highly significant prevalence and incidence gradients are generally noted across the spectrum from normal to severe deficiency.
Conclusions: Pts with Vit D deficiency have a greater prevalence of CV risk factors. Additionally, those deficient in Vit D without prior CV risk factors are much more likely to develop them during follow-up. These findings suggest that Vit D deficiency may play a primary role in development of CV risk factors and CV disease.