Abstract 1267: Genetic Variant rs1051730 C>T in the Nicotinic Acetylcholine Receptor Gene Cluster on Chromosome 15q24 Significantly Predicts Smoking Severity in Coronary Artery Disease Patients
Background: Smoking is a major cause of preventable premature death, mainly due to its strong and dose-dependent impact on coronary artery disease (CAD). Recently, genetic determinants of nicotine dependence (which correlates with the amount of smoked cigarettes rather than with the smoker status per se) have been suggested. No data are available for patients already affected by CAD.
Methods: We genotyped variant rs1051730 C>T in the nicotinic acetylcholine receptor gene cluster on chromosome 15q24 in a large cohort of 1303 consecutive Caucasian patients with angiographically proven CAD.
Results: From our patients, 62.1% had a history of smoking (n=809; 226 current and 581 past smokers). Genotype distributions of variant rs1051730 were not significantly different between patients with a history of smoking and those who had never smoked (ptrend across genotypes=0.471). However, the variant among smokers proved strongly predictive for the average amount of cigarettes smoked per day (24/d, 23/d, and 30/d for subjects with the AA, the AT, and the TT genotypes; p <0.001 for those with the TT genotype vs. carriers of the A allele). This association remained significant after adjustment for age and gender (F=12.4; p <0.001).
Conclusions: Genetic variant rs1051730 C>T in the nicotinic acetylcholine receptor gene cluster significantly predicts smoking severity in patients with angiographically proven CAD.