Abstract 1265: Mean Telomere Length Shortening and Prevalent Type 2 Diabetes Mellitus: A Biracial, Case-Control Study
OBJECTIVE-Recent data have implicated telomere length shortening as a potential risk predictor for type 2 diabetes mellitus (T2DM) and its associated phenotypes. However, to date, epidemiological data are scarce.
RESEARCH DESIGN AND METHODS-Using a case-control study from community-based population sample of the Boston metropolitan area (whites: 424 controls and 432 cases; blacks: 77 controls and 130 cases), we examined the relationship of mean telomere repeat copy number to single gene copy number (TSR) and prevalent T2DM. Associations of TSR with age, race, gender, bodymass index, smoking status, and HbA1c were examined. Logistic regression analysis was performed to evaluate the association of TSR with prevalent T2DM in white and black participants, separately.
RESULTS-The loge-transformed TSR was significantly smaller in the white cases than the white controls (p=0.005). Furthermore, the overall observed TSRs in the black participants were significantly higher than those in the white participants (p=0.0006). In a multivariable adjusted analysis, decreased TSR was significantly associated with prevalent T2DM (odds ratio=1.745; 95%CI=1.012–3.003; p=0.045) in whites, but not in blacks.
CONCLUSIONS-The present investigation has shown an association of telomere length shortening with prevalent T2DM in white, but not in black participants. If corroborated in other studies, our findings further suggest the potential importance of telomere-length dynamics in T2DM.