Abstract 1191: Sex, Race, and Age Distributions of Mean Aortic Wall Thickness in a Multiethnic Population-based Sample
Background: Reference values and age-related changes of the wall thickness of the abdominal aorta have not been described in the general population. We characterized age-, race-, sex-specific distributions, and yearly rates of change of mean aortic wall thickness (MAWT), and associations between MAWT and cardiovascular risk factors in a multi-ethnic population-based probability sample.
Methods: Magnetic resonance imaging measurements of the MAWT were performed on 2,466 white, black, and Hispanic subjects. MAWT race- and sex-specific percentile values across age were estimated using regression analyses. Independent factors for MAWT greater than the predicted 75th percentile adjusted for age, sex, and race/ethnicity were assessed using logistic regression models.
Results: MAWT increased linearly with age in all the groups and across all the percentiles (Figure⇓). MAWT was greater in men than in women. Hispanic women had the thinnest and black men the thickest aortas (median [interquartile range], 1.55 [1.40–1.71] mm and 1.79 [1.60–2.01] mm, respectively). Black men had the highest, and white women the lowest age-related MAWT increase (0.019 and 0.009 mm/year, respectively). Smoking, hypertension, body mass index, LDL-cholesterol, and HDL-cholesterol levels independently predicted MAWT greater than the estimated 75th percentile adjusted for age, sex, and race/ethnicity.
Conclusions: Age, sex, and racial/ethnic differences in MAWT distributions exist in the general population. Such differences should be considered in future investigations assessing aortic atherosclerosis and the effects of anti-atherosclerotic therapies.