Abstract 1185: Low Cardiovascular Risk Profile in Younger Age and Quantity of Coronary Artery Calcium in Older Age: Preliminary Results From the Chicago Healthy Aging Study (CHAS)
Background: Favorable levels of all major cardiovascular disease (CVD) risk factors, i.e., low risk (LR), in younger age are associated with lower subsequent CVD morbidity and mortality, lower health care costs, and better quality of life in older age. The relation of LR status earlier in life to subclinical coronary atherosclerosis, as measured by coronary artery calcium (CAC) in older age, has not been thoroughly examined.
Method: Using data from CHAS, we assessed the association of LR status at baseline (1967–73) (i.e., blood pressure ≤120/≤80 mmHg and no antihypertensive drug use, total cholesterol <200 mg/dl and no lipid-lowering medication, not smoking, BMI <25 kg/m2, and no diabetes) with CAC at follow-up examination (2007– 09). CAC, detected by multi-detector computed tomography, was quantified by Agatston’s method. Multivariate logistic regression was used.
Result: The sample consisted of 534 participants (25% women, 8% African American, 20% LR) ages 25– 42 in 1967–73, free of major ECG abnormalities and myocardial infarction at baseline (mean age 71 at re-survey). LR persons were less likely to have CAC than non-LR persons with average follow-up 38 years. A CAC score of >0 (indicating the presence of any CAC), was observed in 66.9% of LR vs. 83.1% non-LR persons (p<0.001). Corresponding values for CAC score >400 were 8.7% vs. 25.5% (p<0.001). Also, lower number of RFs was associated with lower likelihood of having CAC. For example, the odds of having CAC >0 in persons with baseline LR, 0 RF high, and 1 only RF high compared to those with baseline ≥2 RFs high were lower by 64%, 42%, and 29%, respectively (see Table⇓).
Conclusion: LR status earlier in life is associated with lower CAC prevalence and decreased CAC burden in older age. These findings indicate that LR profile at younger ages may prevent development of advanced coronary atherosclerosis later in life.