Abstract 1176: Exercise Training and Heart Failure: Will Patients Feel Better If They Exercise?
BACKGROUND: The beneficial effects of exercise training on mood disorders and quality of life (QOL) in patients with heart failure (HF) remains controversial, with investigators documenting both positive and negative results. We conducted a secondary analysis to
compare changes in mood disorders, specifically anxiety, depression, hostility, and QOL among four groups of patients in a home-based exercise program who had varying degrees of change in their exercise capacity; and
determine whether there was an association between exercise capacity, mood disorders, and QOL.
METHODS: Seventy-one patients in the exercise arm of a clinical trial were divided into 4 groups based on changes in exercise capacity from baseline to 6 months: Group 1were patients with improvements >10% (n=19); Group 2 were patients with improvements >10% (n=16); Group 3 were patients with reductions >10% (n=9); and Group 4 were patients with reductions >10% (n=27).
RESULTS: Over time, all participants demonstrated significantly lower levels of depression and hostility (P < .001) and significantly higher levels of physical and overall QOL (P=.046). Change scores for the four groups between baseline and 6 months are summarized in Figure 1⇓. All scores showed decreasing effects in the psychological outcomes as changes in exercise capacity worsened.
CONCLUSIONS: An improvement in exercise capacity with exercise training was associated with a decrease in depression and anxiety and an increase in QOL in patients with HF. The controversial findings in prior clinical trials may be the result of variable changes in exercise capacity secondary to non-adherence or other clinical factors.
This research has received full or partial funding support from the American Heart Association, Western States Affiliate (California, Nevada & Utah).