Abstract 1170: Cardiovascular Effects of Major Sporting Events in Men With Coronary Heart Disease During the XXIX Olympiad
Background Exposure to sporting events is associated with adverse cardiovascular events. The mechanisms for this association are unknown. We conducted a controlled exposure to sporting events during XXIX Olympic Games in patients with coronary heart disease to determine the direct effect of sporting effects on myocardial, hemodynamic, autonomic, and thrombotic function.
Methods In a double-blind, randomized, crossover study, 38 men with prior myocardial infarction were exposed, in two separate sessions, to live broadcast of pre-specified matches during XXIX Olympic Games or entertainment television programs. During the exposure, myocardial ischemia was quantified by ST-segment analysis using continuous 12-lead electrocardiography; blood pressure was recorded by ambulatory blood pressure monitor, and heart rate variability was assessed through frequency domain variables. Inflammatory and thrombotic markers were also assessed after exposure.
Results During both exposure sessions, ischemic ST-segment depression was present in all patients, but there was a greater increase in the ischemic burden during exposure to stressful matches (P<0.001). Viewing a stressful match was also associated with a greater increase in both systolic and diastolic blood pressure (P<0.05) and a greater decrease in high- and low-frequency heart rate variability was also observed in subjects exposed to a stressful match (P=0.001). A significant increase in platelet aggregation was also observed in subjects after viewing a stressful match.
Conclusions Exposure to a stressful match promotes myocardial ischemia in men with documented coronary heart disease. Our findings point to ischemic, hemodynamic, automatic and thrombotic mechanisms that may explain in part the observation that major sporting events are associated with adverse cardiovascular events. (ClinicalTrials.gov number, NCT 00795405.)