Abstract 1150: Diacylglycerol Oil-Rich Diet Induces Lower Glucose-Dependent Insulinotropic Polypeptide and Insulin Responses in Obese Men
Introduction: Obesity is a major risk factor for cardiovascular disease (CVD). Glucose-dependent insulinotropic polypeptide (GIP) directly links overnutrition to obesity. A higher fat to carbohydrate intake ratio amplifies the GIP response. A diacylglycerol (DAG)-enriched diet improves postprandial hyperinsulinemia, lipemia, and visceral fat accumulation compared to a common triacylglycerol (TAG)-enriched diet. Our aim was to assess the effect of a DAG enriched diet on postprandial GIP and insulin responses in obese subjects.
Methods: Using a double-blind cross-over design, 9 obese nondiabetic men (mean BMI: 30.1) were randomly assigned to one of two single administration tests with a 2-week washout period. A 4240-kJ meal containing 30g TAG oil or DAG oil (P:F:C=14:35:52) was administered after a 12-h fasting period. Blood samples were obtained to measure serum lipids, glucose, GIP, and insulin levels prior to and 0.5, 1, 2, 4, 6, and 8 h after the meal.
Results: Relative to the TAG diet, the DAG diet resulted in significantly lower serum GIP and insulin, but not glucose, levels at 2h after the meal, as well as significantly smaller incremental areas under the curve (IAUC) for GIP and insulin levels (figure⇓). The reduced insulin and GIP responses when consuming the DAG-enriched meal were positively correlated (r=0.812, p=0.008). Serum triglyceride-rich lipoprotein cholesterol levels were also significantly lower in subjects consuming DAG oil compared to TAG oil.
Conclusions: Replacing common TAG oil with DAG oil in a standard diet improves postprandial GIP and insulin responses and may be a useful dietary approach to prevent CVD in the obese population.