Abstract 1145: Acute and Chronic Coffee Consumption Has a Less Potent Effect on Aortic Stiffness Than Caffeine
Objective: Aortic stiffness is an independent marker of cardiovascular risk. We examined whether there is a differential acute and chronic effect of coffee and caffeine on aortic stiffness.
Methods: The acute effect of coffee and caffeine were studied in 24 healthy volunteers (11 habitual-13 nonhabitual coffee consumers) on 4 separate occasions receiving:
decaffeinated triple espresso,
240mg of caffeine alone (amount contained in a triple espresso) and
The effect of a 2-week long, daily coffee and caffeine consumption was examined in 10 habitual volunteers.
Results: Acute study (upper panel): In the whole population, both coffee and caffeine increased carotid-femoral pulse wave velocity (PWV), however, caffeine led to a more potent effect. Habitual and nonhabitual drinkers demonstrated similar changes with coffee, whereas the effect of caffeine was more potent in nonhabitual compared to habitual drinkers. Chronic study (lower panel): PWV was significantly increased with caffeine compared to placebo (by 0.40 m/sec, P<0.05). Furthermore, PWV was significantly increased with coffee compared to decaffeinated coffee (by 0.57 m/s, P<0.05). Both caffeine and coffee increased PWV, however, the effect of caffeine was more pronounced (by 0.31 m/sec, P<0.05).
Conclusion: Both coffee and caffeine increase PWV, however caffeine leads to a more potent acute and chronic response. Caffeine has a more unfavorable acute effect than coffee in nonhabitual compared with habitual drinkers. This finding indicate that substances other caffeine may partially counterbalance the unfavourable effect of caffeine on the cardiovascular system.