Abstract 1140: Does Gender Influence C-Reactive Protein Concentration Among US Children and Young Adults? Results From the National Health and Nutrition Examination Survey 1999–2006
Background: The association between gender and C-reactive protein (CRP) is poorly studied in children and young adults. Also, it is not clear whether the use of oral contraceptive pills (OCP’s) may modulate the association between gender and CRP in this population.
Objective: To investigate the association between gender and CRP in children and young adults and whether this association is modified by the use of OCP’s in young women.
Methods: A cross-sectional study was done in children and young adults 12 to 19 years of age who participated in the NHANES Survey between 1999 and 2006. CRP was considered elevated if it was ≥3 mg/L. We determined the prevalence of elevated CRP and multivariate logistic regression was done to investigate the association between gender and elevated CRP after adjusting for other cardiovascular risk factors. Stratified analysis was done across groups of females with and without use of OCP’s to obtain stratum specific estimates for gender.
Results: The prevalence of elevated CRP was 13% in a total of 8042 participants. 15% of the females and 10% of the males had elevated CRP levels. Multivariate analyses showed that female gender and Ponderal index (PI) had significant association with elevated CRP after adjusting for demographic and other cardiovascular risk factors. Females were 2.5 times more likely to have elevated CRP compared to males. However, to account for the effect of OCP usage in females, a stratified analysis was done which showed that compared to males, females who ever used an OCP were 8 times more likely to have elevated CRP, whereas females without history of usage of OCP did not differ from males for the odds of having an elevated CRP (Table⇓).
Conclusions: While PI had significant association with elevated CRP in this age group, use of OCP’s may account for most of the gender difference.